Isoform-Specific Functions of Phosphoinositide 3-Kinases: p110 but Not p110 Promotes Optimal Allergic Responses In Vivo
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منابع مشابه
Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers.
Class IA phosphoinositide 3-kinases (PI3Ks) signal downstream of tyrosine kinases and Ras and control a wide variety of biological responses. In mammals, these heterodimeric PI3Ks consist of a p110 catalytic subunit (p110alpha, p110beta, or p110delta) bound to any of five distinct regulatory subunits (p85alpha, p85beta, p55gamma, p55alpha, and p50alpha, collectively referred to as "p85s"). The ...
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Class I phosphoinositide 3-kinase contains four isoforms of the catalytic subunit, p110 , , , and . At physiological levels of expression, the wild-type p110 isoform lacks oncogenic potential, but gain-of-function mutations and overexpression of p110 are correlated with oncogenicity. The p110 , , and isoforms induce transformation of cultured cells as wild-type proteins. This oncogenic potentia...
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The p110 isoforms of phosphoinositide 3-kinase (PI3K) are acutely regulated by extracellular stimuli. The class IA PI3K catalytic subunits (p110 , p110 , and p110 ) occur in complex with a Src homology 2 (SH2) domain-containing p85 regulatory subunit, which has been shown to link p110 and p110 to Tyr kinase signaling pathways. The p84/p101 regulatory subunits of the p110 class IB PI3K lack SH2 ...
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Phosphoinositide 3-kinases (PI3Ks) are important signalling enzymes in most cell types. Recent gene targeting studies have shed light on the importance of this family of lipid kinases in the immune system, and the complex mechanisms by which these kinases are regulated in vivo. We have recently reported a phenotype of mice in which the p110 delta PI3K catalytic subunit was inactivated by point ...
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Phosphatidylinositol 3-kinases (PI3Ks) play a critical role in regulating B cell receptor- and T cell receptor-mediated signaling. However, their role in natural killer (NK) cell development and functions is not well understood. Using mice expressing p110 delta(D910A), a catalytically inactive p110 delta, we show that these mice had reduced NK cellularity, defective Ly49C and Ly49I NK subset ma...
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